Omega-3 Predicts Death Risk Better Than Cholesterol

Omega-3 Predicts Death Risk Better Than Cholesterol

Blood levels of omega-3 fatty acids are a better predictor of death risk from any cause than cholesterol, according to a study published in the Journal of Clinical Lipidology. Results found that death from any cause was reduced by 33 percent when comparing people with the highest levels of omega-3s to those with the lowest levels.

Omega-3 fatty acids are healthy oils. Two omega-3 oils — EPA and DHA —are found in cold water fish, such as salmon, sardines, and mackerel, and fish oil supplements. Plants and seeds contain another type of omega-3 called ALA (alpha-linolenic acid).

The study measured serum cholesterol levels and blood levels of EPA and DHA omega-3 fatty acids in 2,500 people in order to analyze the risk for developing certain diseases.  All of the individuals were free of known cardiovascular disease (CVD) when the study began.

While the researchers primarily focused on total mortality (death from any cause), they also tracked deaths from CVD, cancer, and other causes. In addition, they reported the associations between levels of omega-3’s and the risk for any CVD event, whether it was a heart attack or stroke, and whether or not it was fatal.

They expected that cholesterol levels would predict the risk of dying more accurately than omega-3 levels. However, cholesterol wasn’t associated with predictions of premature death, but omega-3s were related to four out of five outcomes the researchers analyzed.

The new study’s finding of an overall reduction in death risk suggest that EPA and DHA have a wide range of helpful actions throughout the body, not just in the cardiovascular system.

“We all know that the serum cholesterol level is a major risk factor for CVD, and since the latter is a major cause of death in the Western world, it would be reasonable to expect that a high cholesterol level would portend higher risk for premature death,” said lead author Dr. William Harris. “This did not turn out to be the case here.

“When baseline serum cholesterol levels were substituted for the Omega-3 Index in the same multi-variable models, the former was not significantly associated with any of the tracked outcomes whereas the latter was related to 4 of the 5 outcomes assessed,” Harris noted.

Previous studies have found that omega-3 fatty acids reduce the risk of heart disease. Results from a 2017 study that reviewed 14 randomized, controlled trials found that EPA and DHA omega-3 fatty acids reduced the risk of cardiac death up to 30 percent.

The American Heart Association recommends eating two servings of fish each week. Two servings supply 250-500 mg of EPA and DHA per day. In addition, the AHA also recommends 1 gram of EPA and DHA per day for those who have been diagnosed with heart disease.

According to the American Heart Association, cardiovascular diseases, including heart attack and stroke, account for one out of every three deaths in the U.S.

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